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Caroline's mind was put on a storage device and put into GLaDOS' body, but the mainframe of GLaDOS took over the personality of Caroline and flooded the whole entire facility with deadly neurotoxins and made a lot of people test, so the remaining workers put the Personality Cores on GLaDOS to hold back the mainframe, but it only did so much. That's why when you remove the cores in Portal 1, GLaDOS changes into a much more evil person, because the mainframe was allowed to act on it's own. Also, in Portal 2, PotaDOS acts much nicer because she isn't GLaDOS anymore, she's Caroline since the mainframe has stopped inducing evil onto her, she just doesn't know it until she hears her human voice later on.

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